The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jan. 08, 2002
Filed:
Aug. 14, 2000
Elisabeth Defossa, Idstein, DE;
Uwe Heinelt, Wiesbaden, DE;
Otmar Klingler, Rodgau, DE;
Gerhard Zoller, Schöneck, DE;
Fahad A. Al-Obeidi, Tucson, AR (US);
Armin Walser, Tucson, AR (US);
Peter Wildgoose, Oberursel, DE;
Hans Matter, Langenselbold, DE;
Aventis Pharma Deutschland GmbH, Frankfurt am Main, DE;
Abstract
The present invention relates to the inhibition of blood clotting proteins, and more particularly, to indole derivatives of formula (I), in which R , R , R R , R , R , R and A are defined as indicated in the claims. The compounds of formula (I) are inhibitors of the blood clotting enzyme factor Xa. The invention also relates to processes for the preparation of the compounds of formula (I), to methods of inhibiting factor Xa activity and of inhibiting blood clotting, to use of the compounds of formula (I) in the treatment and prophylaxis of diseases which can be cured or prevented by the inhibition of factor Xa activity such as thromboembolic diseases, and to the use of the compounds of formula (I) in the preparation of medicaments to be applied in such diseases. The invention further relates to compositions containing a compound of formula (I) in admixture or otherwise in association with an inert carrier, in particular pharmaceutical compositions containing a compound of formula (I) together with pharmaceutically acceptable carrier substances and/or auxiliary substances.