The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jan. 08, 2002
Filed:
Dec. 13, 1999
Applicant:
Inventors:
Nabil El Tayar, Milton, MA (US);
Steven Blechner, West Bridgewater, MA (US);
Brad Jameson, Milton, MA (US);
Mark Tepper, Canton, MA (US);
Assignee:
Applied Research Systems ARS Holding N.V., Curacao, NL;
Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
A61K 3/810 ; A61K 3/812 ; C07K 7/00 ; C07K 7/64 ;
U.S. Cl.
CPC ...
A61K 3/810 ; A61K 3/812 ; C07K 7/00 ; C07K 7/64 ;
Abstract
The present invention relates to peptidomimetics capable of inhibiting CD28 and/or CTLA-4 interaction with CD80 (B7-1) and CD86 (B7-2) and having a core amino acid sequence, LeuMetTyrProProProTyrTyr, corresponding to residues 2 to 9 of SEQ ID NO:1. The present invention also relates to pharmaceutical compositions and a method of treating pathologies and disorders which are improved by inhibition of CD28 and/or CTLA-4 interaction with CD80 and CD86.