The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jan. 01, 2002
Filed:
Oct. 23, 2000
Jacobus A. J. Den Hartog, Weesp, NL;
Gerben M. Visser, Weesp, NL;
Bartholomeus J. Van Steen, Weesp, NL;
Martinus T. M. Tulp, Weesp, NL;
Eric Ronken, Weesp, NL;
Cornelis G. Kruse, Weesp, NL;
Josephus H. M. Lange, Weesp, NL;
Abstract
The present invention relates to a group of novel benzisoxazole derivatives which are potent and selective antagonists of the dopamine D4-receptor. The compounds have general formula (I) wherein (R ) represents 0, 1, or 2 substituents, which can be the same or different, from the group C -alkyl or alkoxy, halogen, trifluoromethyl, nitro, amino mono- or dialkyl (C )-amino, sulfonyl-(C )alkyl or -alkoxy, sulfonyl trifluoromethyl, sulfonyl amino, and sulfonyl mono- or dialkyl (C )-amino, X is O, S, NH or NCH , Y represents CH , or (CH ) , (R ) represents 0, 1, or 2 substituents, which can be the same or different, from the group methyl and ethyl, or (R ) is a methylene bridge or ethylene bridge, A is a group —CH —(CRH) — wherein R is hydrogen or methyl and p is 0 or 1, and B represents 2- or 3-indolyl or 2-benzimidazolyl, which groups may be substituted at carbon with 1 or 2 substituents from the group C- -alkyl or alkoxy, halogen, trifluoromethyl, nitro, amino, mono- or dialkyl (C )amino, sulfonyl-(C )alkyl or -alkoxy, sulfonyl trifluoromethyl, sulfonyl amino, and sulfonyl mono- or dialkyl (C )-amino.