The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jan. 01, 2002
Filed:
Jan. 31, 2000
Keiko Tsuganezawa, Kanagawa, JP;
Hajime Karasuyama, Koganei-shi, Tokyo 184-0015, JP;
Other;
Abstract
The present invention provides an antibody which recognizes a human pre-B cell receptor and does not recognize a human pro-B cell. The invention also provides an antibody which reacts with a VpreB molecule, one of the constituents of an SL chain of a human pre-B cell receptor expressed on the membrane surface of a human pre-B cell, or a VpreB molecule expressed within a human pro-B cell, but does not react with a &lgr;5 molecule of the surrogate light chain, and whose reactivity is such that a human pre-B cell or a human pro-B cell reacted with the antibody can be detected microscopically. The invention further provides a method for diagnosing which differentiation stage of B cells acute lymphoblastic leukemia in childhood stems from, by using an antibody which recognizes a human pre-B cell receptor, and does not recognize a human pro-B cell, an antibody which recognizes a VpreB molecule of a surrogate light chain constituting a human pre-B cell receptor, an antibody which recognizes a &lgr;5 molecule of the surrogate light chain constituting a human pre-B cell receptor, and an antibody which recognizes a B cell.