The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Dec. 18, 2001
Filed:
Jul. 27, 1999
Klaus P. Hirth, San Francisco, CA (US);
Elaina Mann, Alameda, CA (US);
Laura K. Shawyer, San Francisco, CA (US);
Axel Ullrich, Munchen, DE;
Istvan Szekely, Dunakeszi, HU;
Tamas Bajor, Budapest, HU;
Janis Haimichael, Budapest, HU;
Laszlo Orfi, Budapest, HU;
Alex Levitzki, Jerusalem, IL;
Aviv Gazit, Jerusalem, IL;
Peng Cho Tang, Moraga, CA (US);
Reiner Lammers, Munchen, DE;
Other;
Abstract
The present invention concerns compounds which can inhibit platelet derived growth factor receptor (PDGF-R) activity, preferably such compounds also inhibit the activity other members of the PDGF-R super family and are selective for members of the PDGF-R super family. The PDGF-R super family includes PDGF-R and PDGF-R related kinases Flt, and KDR. The featured compounds are active on cell cultures to reduce the activity of the PDGF-R and preferably one or more PDGF-R related kinases. An example of a featured compound, A10 (see FIG.,), and its ability to inhibit growth of tumor cells in vivo is described below. Using the present application as guide other compounds able to inhibit PDGF-R and preferably Flt and/or KDR can be obtained. Such compounds are preferably used to treat patients suffering from cell proliferative disorders characterized by inappropriate PDGF-R activity.