The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Dec. 11, 2001
Filed:
Mar. 15, 1999
Stephen Paul Collingwood, Crawley, GB;
Heinz Ernst Moser, Horsham, GB;
Karl-Heinz Altmann, Reinach, CH;
Mark Edward Douglas, Macclesfield, GB;
ISIS Pharmaceuticals, Inc., Carlsbad, CA (US);
Abstract
A compound of formula (I) wherein B,is a radical of a nucleoside base, R,is hydrogen or a hydroxy-protecting group, R,is hydrogen, hydroxy or a 2′-nucleoside-modifying atom or group, R,is an unsubstituted or substituted C,to C,alkyl, C,to C,alkenyl, C,to C,cycloalkylalkyl, C,to C,aryl or C,to C,aralkyl group, and Z is halogen or a group of formula (II) where R,and R,are each independently an unsubstituted or substituted C,to C,alkyl, C,to C,alkenyl, C,to C,cycloalkylalkyl, C,to C,aryl or C,to C,aralkyl group, or R,is said group and R,is hydrogen or R,and R,together with the nitrogen atom to which they are attached denote a five- to thirteen-membered heterocyclic ring, or Z is a group of formula (III): Nuc-O—, where Nuc is the residue of a natural or synthetic nucleoside or oligonucleotide after removal of a 5′-hydroxyl group therefrom attached through a 5′-methylene thereof to the indicated oxygen atom.