The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Dec. 11, 2001
Filed:
Aug. 07, 2000
Applicant:
Inventors:
Weidong Xiao, Jenkintown, PA (US);
Matthew J. During, Philadelphia, PA (US);
Lei Cao, Philadelphia, PA (US);
Assignee:
Neurologix, Inc., Great Neck, NY (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C12N 1/563 ; C12N 1/564 ; C12N 1/5864 ; C07H 2/104 ;
U.S. Cl.
CPC ...
C12N 1/563 ; C12N 1/564 ; C12N 1/5864 ; C07H 2/104 ;
Abstract
The present invention provides methods and compositions for preparations of recombinant parvovirus virions with a reduced number of replication competent particles. The compositions of the present invention include nucleic acids encoding parvovirus helper functions which contain at least one non-native intron sequence. The present invention also includes helper function vectors, host cells transfected with the helper function vectors, methods of using the helper function vectors, and recombinant parvovirus virions produced by such methods.