The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Dec. 04, 2001
Filed:
Oct. 18, 1996
Applicant:
Inventors:
Assignee:
Board of Regents, The University of Texas System, Austin, TX (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 3/170 ; A61K 4/800 ; A61K 9/127 ; A01N 6/300 ;
U.S. Cl.
CPC ...
A61K 3/170 ; A61K 4/800 ; A61K 9/127 ; A01N 6/300 ;
Abstract
The present invention relates to methods for the inhibition, of the gene product of the neu oncogene, p185 neu tyrosine kinase. Over-expression of the neu oncogene can lead to chemoresistance. The present invention discloses the functional domains of E1A responsible for the repression of neu-mediated transformation. Further the invention discloses methods for the novel use of mini-E1A in combination with chemotherapeutic drugs and/or tyrosine kinase inhibitors. Mini-E1A may be used in the treatment of cancer and other disease.