The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Nov. 27, 2001
Filed:
May. 17, 1999
David E. Clemmer, Gosport, IN (US);
James P. Reilly, Bloomington, IN (US);
Advanced Research and Technology Institute, Inc., Indianapolis, IN (US);
Abstract
An ion mobility and mass spectrometer instrument includes an ion source region coupled to an ion mobility spectrometer having an ion outlet coupled to a quadrupole mass filter. An output of the filter is coupled to a collision cell which has an ion outlet coupled to an ion acceleration region of a mass spectrometer such as a time of flight mass spectrometer. The instrument is particularly well suited for sequencing analysis wherein a sample is ionized and a resulting three-dimensional ion spectrum (ion intensity vs. ion mobility and ion mass) is observed. If the spectrum reveals that no ions overlap in mobility values, the collision cell is filled with a suitable buffer gas and the instrument is reactivated whereby a complete three-dimensional spectrum of parent and daughter ions results. If, however, the original spectrum reveals that two or more ions overlap in ion mobility values, the collision cell is filled with a buffer gas and the quadrupole mass filter is controlled to selectively filter out all but one of the ions having overlapping mobility values. The instrument is reactivated, and the quadrupole mass filter is selectively controlled, as many times as mobility overlap occurs to thereby provide complete three-dimensional spectra of parent and daughter ions resulting from fragmentation. Various configurations of mass filter, ion trap and collision cell positioning, relative to the ion mobility and mass spectrometer instruments, are contemplated.