The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Nov. 27, 2001
Filed:
Jun. 17, 1999
David J. Harris, Lexington, MA (US);
Edward R. Lee, Natick, MA (US);
Canwen Jiang, Marlboro, MA (US);
Seng H. Cheng, Wellesley, MA (US);
Mathieu Lane, Cambridge, MA (US);
Genzyme Corporation, Cambridge, MA (US);
Abstract
Cystic fibrosis transmembrane conductance regulator (CFTR) is a chloride (Cl,) channel regulated by phosphorylation and intracellular nucleotides. CFTR is the major Cl,transport pathway in airway epithelial cells. The abnormal transepithelial Cl,transport and subsequent defective fluid transport caused by CF is a result of the genetic mutations of the gene coding for the CFTR protein. The present invention is directed to the novel use of ionophores as artificial Cl,transport pathways into CF epithelia to treat the defective Cl,and fluid transport lonophores and in particular, small molecule ionophores, represent a potential novel means of treating CF. The invention also includes using an ionophore to generate chloride secretion on intact monolayers of airway epithelia cells and other epithelia cells by administering an ionophore to a mammal.