The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Nov. 27, 2001

Filed:

Jun. 25, 1999
Applicant:
Inventors:

Howard Brody, Davis, CA (US);

Deborah S. Yaver, Davis, CA (US);

Michael Lamsa, Davis, CA (US);

Kim Hansen, Vaerlose, DK;

Assignee:

Novozymes Biotech, Inc, Davis, CA (US);

Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
C12N 1/509 ; C12N 1/563 ; C12N 1/15 ; C12P 2/106 ; C07H 2/104 ;
U.S. Cl.
CPC ...
C12N 1/509 ; C12N 1/563 ; C12N 1/15 ; C12P 2/106 ; C07H 2/104 ;
Abstract

The present invention relates to methods for modifying the production of a polypeptide, comprising: (a) introducing a nucleic acid construct into a cell, wherein the cell comprises a DNA sequence encoding a polypeptide, under conditions in which the nucleic acid construct integrates into the genome of the cell at a locus not within the DNA sequence encoding the polypeptide to produce a mutant cell, wherein the integration of the nucleic acid construct modifies the production of the polypeptide by the mutant cell relative to the cell when the mutant cell and the cell are cultured under the same conditions; and (b) identifying the mutant cell with the modified production of the polypeptide.


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