The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Nov. 13, 2001
Filed:
Jul. 25, 1997
Fu-Tai A. Chen, Brea, CA (US);
Ramon A. Evangelista, Placentia, CA (US);
Gene G. Y. Shen, Diamond Bar, CA (US);
Chan S. Oh, Chino Hills, CA (US);
Beckman Coulter, Inc., Fullerton, CA (US);
Abstract
The separation of enantiomeric pairs of compounds by capillary electrophoresis using highly sulfated &agr;-, &bgr;-, and &ggr;-cyclodextrins as chiral selectors is described herein. These charged cyclodextrins have a higher degree of sulfation and narrower heterogeneity than previous cyclodextrin derivatives. CE analyses using highly sulfated cyclodextrins produce improved resolution of a wide variety of chiral drugs, particulaly neutral compounds and amines. The highly sulfated &agr;-,&bgr;-, and &ggr;-cyclodextrins produce separations which complement each other to further expand the number of neutral and basic drugs that can be resolved by capillary electrophorsis.