The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Nov. 06, 2001
Filed:
Jan. 15, 1998
Applicant:
Inventors:
Leslie A. Holladay, Mountain View, CA (US);
Kevin R. Oldenburg, Fremont, CA (US);
Assignee:
ALZA Corporation, Mountain View, CA (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A01N 1/30 ; C07K 7/00 ;
U.S. Cl.
CPC ...
A01N 1/30 ; C07K 7/00 ;
Abstract
Methods for modifying polypeptide agents to enhance their transdermal electrotransport flux are provided. The polypeptide is modified by reducing the potential of the polypeptide for forming &agr;-helical or &bgr;-sheet segments. In particular, amino acid residues known to stabilize &agr;-helical and &bgr;-sheet segments can be replaced with destabilizing residues and known helix breakers. Modified molecules and compositions including the molecules are also provided.