The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 30, 2001
Filed:
Dec. 09, 1999
Applicant:
Inventor:
Vijaya B. Kumar, Ellisville, MO (US);
Assignee:
St. Louis University, St. Louis, MO (US);
Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
A61K 4/800 ; C07H 2/104 ; C07H 2/102 ; C12N 1/585 ; C12N 1/586 ;
U.S. Cl.
CPC ...
A61K 4/800 ; C07H 2/104 ; C07H 2/102 ; C12N 1/585 ; C12N 1/586 ;
Abstract
An antisense compound comprising nucleotides complementary to a nucleic acid sequence coding for amyloid precursor protein (APP), wherein the antisense compound inhibits the expression of an amyloid beta protein (A&bgr;P) portion of the amyloid precursor protein coding sequence while permitting the expression of at least a portion of the amyloid precursor protein polynucleotide 5′ to the A&bgr;P portion of the amyloid precursor protein coding sequence. Pharmaceutical compositions and formulations containing the compound and methods of using the compound to regulate A&bgr;P expression in cells and tissues and to treat disease are also provided.