The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 30, 2001
Filed:
Jan. 03, 1997
Maureen T. Cronin, Los Altos, CA (US);
Charles G Miyada, San Jose, CA (US);
Earl A. Hubbell, Los Angeles, CA (US);
Mark Chee, Palo Alto, CA (US);
Stephen P. A. Fodor, Palo Alto, CA (US);
Xiaohua C. Huang, Mountain View, CA (US);
Robert J. Lipshutz, Palo Alto, CA (US);
Peter E. Lobban, Mountain View, CA (US);
MacDonald S. Morris, Felton, CA (US);
Edward L. Sheldon, San Diego, CA (US);
Affymetrix, Inc., Santa Clara, CA (US);
Abstract
The invention provides arrays of immobilized probes, and methods employing the arrays, for detecting mutations in the biotransformation genes, such as cytochromes P450. For example, one such array comprises four probe sets. A first probe set comprises a plurality of probes, each probe comprising a segment of at least three nucleotides exactly complementary to a subsequence of a reference sequence from a biotransformation gene, the segment including at least one interrogation position complementary to a corresponding nucleotide in the reference sequence. Second, third and fourth probe sets each comprise a corresponding probe for each probe in the first probe set. The probes in the second, third and fourth probe sets are identical to a sequence comprising the corresponding probe from the first probe set or a subsequece of at least three nucleotides thereof that includes the at least one interrogation position, except that the at least one interrogation position is occupied by a different nucleotide in each of the four corresponding probes from the four probe sets.