The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 30, 2001
Filed:
May. 03, 1999
Applicant:
Inventors:
George A. Cates, Richmond Hill, CA;
Sonia E. Sanhueza, Willowdale, CA;
Raymond P. Oomen, Schomberg, CA;
Michel H. Klein, Willowdale, CA;
Assignee:
Aventis Pasteur Limited, Toronto, CA;
Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
A61K 3/9155 ; C12N 7/02 ; C12N 7/04 ; A23J 1/00 ;
U.S. Cl.
CPC ...
A61K 3/9155 ; C12N 7/02 ; C12N 7/04 ; A23J 1/00 ;
Abstract
The fusion (F) protein, attachment (G) protein and matrix (M) protein of respiratory syncytial virus (RSV) are isolated and purified from respiratory syncytial virus by mild detergent extraction of the proteins from concentrated virus, loading the protein onto a hydroxyapatite or other ion-exchange matrix column and eluting the protein using mild salt treatment. The F, G and M proteins, formulated as immunogenic compositions, are safe and highly immunogenic and protect relevant animal models against decreased caused by respiratory syncytial virus infection.