The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 23, 2001
Filed:
Sep. 07, 1999
Applicant:
Inventors:
Ernest John McEachern, White Rock, CA;
Francisco Dean Toste, Mississauga, CA;
Barry Martin Trost, Los Altos Hills, CA (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07D / ; C07C / ; C07C 4/102 ;
U.S. Cl.
CPC ...
C07D / ; C07C / ; C07C 4/102 ;
Abstract
Nucleophilic oxygen species, such as primary alcohols, carboxylates, and water, are added to vinyl epoxides in a highly regioselective and enantioselective manner, providing a convenient route to enantiomerically enriched 1,2-diols and oxygen-containing heterocycles. The reaction employs a chiral Pd(0) complex and a borane or borate as co-catalysts Also described are similar additions of nitrogen nucleophiles, and the addition of carbonates to vinyl epoxides using a chiral Pd(0) catalyst.