The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Oct. 09, 2001

Filed:

Feb. 11, 2000
Applicant:
Inventors:

John A. Lindbo, Vacaville, CA (US);

Gregory P. Pogue, Vacaville, CA (US);

Thomas H. Turpen, Vacaville, CA (US);

Assignee:

Large Scale Biology Corporation, Vacaville, CA (US);

Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
C12N 1/582 ; C12N 1/500 ; C12P 1/934 ; C07H 2/104 ; C07H 2/102 ;
U.S. Cl.
CPC ...
C12N 1/582 ; C12N 1/500 ; C12P 1/934 ; C07H 2/104 ; C07H 2/102 ;
Abstract

This invention is directed to a plus strand RNA viral vector for transformation of a host organism with a foreign RNA, and expression of said foreign RNA. The foreign RNA is inserted into an infective RNA viral segment containing cis-acting viral replication elements, and allowed to infect the host organism. The RNA vector is modified to obtain infectivity by including an intervening sequence between the cap and the 5′ end. The modified RNA is able to tolerate the exogeneous RNA segment without disrupting the replication of the modified RNA, in the absence of a trans-acting viral replication element in a single component plant virus host cell.


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