The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Oct. 02, 2001

Filed:

Sep. 23, 1999
Applicant:
Inventor:

Ira Shafran, Winter Park, FL (US);

Assignee:

Other;

Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
G01N 3/3569 ; C12N 1/531 ; C12Q 1/68 ; C12P 1/934 ;
U.S. Cl.
CPC ...
G01N 3/3569 ; C12N 1/531 ; C12Q 1/68 ; C12P 1/934 ;
Abstract

A composition and method for detecting Crohn's disease include the use of serological testing as a rapid and simple way to diagnose Crohn's disease. The serological tests were based on the use of the two recombinant clones isolated from an,genomic library that expressed 35K and 36K MW antigens. Antigen p35 was isolated from Johne's disease sera (acid-fast bacilli form) and p36, from human CD sera (spheroplast form). The combined use of p35 and p36 recombinant antigens provides a highly specific and sensitive test to demonstrate the humoral immune response of CD patients to,. A serologic kit is disclosed including the composition including the combined p35 and p36 antigens. A treatment methodology utilizes antimycobacterial drugs, preferably upon patients prescreened for the presence of,. A particular antibiotic regimen includes an administration of both rifabutin and clarithromycin, which has been found to be particularly effective in alleviating the symptoms of Crohn's disease.


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Shafran, Ira. (2001). Crohn's disease diagnostic and treatment methods and compositions (U.S. Patent No. 6297015). U.S. Patent and Trademark Office. https://idiyas.com/patent/badge/6297015

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