The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Sep. 25, 2001
Filed:
Jul. 05, 1996
James G. Wetmur, Scarsdale, NY (US);
The Mount Sinai School of Medicine of the City University of New York, New York, NY (US);
Abstract
Isolated nucleic acids which encode a thermostable protein that enhances specific binding of a thermostable mismatch binding protein to bulge loops in a heteroduplex nucleic acid and recombinant vectors comprising nucleic acid which encodes a thermostable protein that enhances specific binding of a thermostable mismatch binding protein to bulge loops in a heteroduplex nucleic acid are disclosed. Also disclosed are isolated thermostable proteins that enhance specific binding of a thermostable mismatch binding protein to bulge loops in a heteroduplex nucleic acid and host cells comprising a recombinant gene which can express a thermostable protein that enhances specific binding of a thermostable mismatch binding protein to bulge loops in a heteroduplex nucleic acid. Further disclosed are methods of reducing DNA misincorporation in an amplification reaction, methods for detecting a nucleic acid which includes a specific sequence, methods for amplifying a nucleic acid comprising a specific sequence, and methods for selecting against a nucleic acid comprising specific sequence.