The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Sep. 18, 2001

Filed:

Oct. 27, 1997
Applicant:
Inventors:

Edgardo Delfino Carosella, Paris, FR;

Philippe Moreau, Viry-Chatillon, FR;

Eliane Gluckman, Paris, FR;

Marek Kirszenbaum, Orsay, FR;

Assignee:
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07H 2/102 ; C07H 2/104 ; C12Q 1/68 ; C12N 1/500 ;
U.S. Cl.
CPC ...
C07H 2/102 ; C07H 2/104 ; C12Q 1/68 ; C12N 1/500 ;
Abstract

Transcripts of the major histocompatibility complex (MHC) Class I HLA-G gene which are present in foetal trophoblasts and/or in adult circulating mono-nuclear cells, as well as their applications. Either the said transcripts comprise, in succession in the 5′ to 3′ direction: a fragment encoding the signal peptide (exon 1), a fragment encoding the &agr;1 domain (exon 2), a fragment encoding the &agr;2 domain (exon 3), a fragment encoding the transmembrane TM domain (exon 5), a fragment encoding the cytoplasmic domain (exon 6) and the 3′ untranslated fragment (exon 8), which sequence is designated HLA-G4, or the said transcripts comprise intron 4.


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