The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Sep. 18, 2001
Filed:
Sep. 20, 1996
Jurgen Conrad, Berlin, DE;
Ludger Dinkelborg, Berlin, DE;
Sebastian Erber, Ergolding, DE;
Cornelius Frommel, Zeuthen, DE;
Wolfgang Hohne, Berlin, DE;
Wolfgang Kramp, Berlin, DE;
Gabriele Kuttner, Berlin, DE;
Reinhard Malin, Berlin, DE;
Hans Martin Schier, Strausberg, DE;
Jens Schneider-Mergener, Berlin, DE;
Renate Steinbrecher, Berlin, DE;
Institut Fue Diagnostikforschung GmbH, Berlin, DE;
Abstract
These invention relates to metal-complexing, cysteine-free peptides which may be coupled to an organ-specific probe directly or via a linker and are thus enriched as conjugates specifically in tumors, organs, tissues or centers of inflammation. The organ-specific probes used are, for example, antibodies or part-sequences of antibodies against tumor-associated antigens, e.g. the carcino-embryonal antigen (CEA, which are thus specifically enriched in tumors. The invention also relates to processes for producing the metal-complexing cysteine-free peptides and their conjugates. The present invention also relates to the use of the conjugates as components of a kit for in vivo diagnosis or in vivo therapy and radio-pharmaceuticals containing these conjugates together with radio-isotopes. The organ-specific conjugates are used to image tumors, organs or centers of inflammation.