The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Sep. 18, 2001
Filed:
May. 19, 1998
Mario Ferrari, Milan, IT;
Paola Gnocchi, Stresa, IT;
Maria Chiara Fornasiero, Vigevano, IT;
Francesco Colotta, Milan, IT;
Roberto D′Alessio, Cinisello Balsamo, IT;
Anna Maria Isetta, Rho, IT;
Pharmacia & Upjohn SpA, Milan, IT;
Abstract
A product containing: (a) an immunosuppressant agent (A) and (b) at least one immunosuppressant 2,2′-bi-1H-pyrrole compound (B) having formula (I) wherein R,is hydrogen, phenyl, C,-C,alkyl or C,-C,alkenyl, wherein the alkyl and alkenyl groups are unsubstituted or substituted by 1 to 3 substituents, which are the same or different, chosen independently from halogen, C,-C,alkoxy, hydroxy, aryl and aryloxy; R,is hydrogen, C,-C,alkyl, cyano, carboxy or (C,-C,alkoxy)carbonyl; R,is halogen, hydroxy or C,-C,alkoxy unsubstitued or substituted by phenyl; R,is hydrogen, C,-C,alkyl or phenyl; each of R,and R,, which are the same or different, is independently hydrogen, C,-C,alkanoyl, C,-C,alkenoyl, phenyl, C,-C,alkyl or C,-C,alkenyl; or two of R,, R,and R,, taken together, form a C,-C,polymethylene chain, which is unsubstituted or substituted by a C,-C,alkyl, by a C,-C,alkenyl or by a C,-C,alkylidene group; or a pharmaceutically acceptable salt thereof; as a combined preparation for simultaneous, separate or sequential use in immunosuppressant therapy, said preparation having a potentiated immunosuppressive activity with respect to products containing either the immunosuppressive agent (A) or the 2,2′-bi-1H-pyrrole immunosuppressive compound (B).