The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Sep. 11, 2001
Filed:
Aug. 31, 1999
Applicant:
Inventors:
Grant Andrew McNaughton-Smith, Morrisville, NC (US);
Gregory Cooksey Rigdon, Durham, NC (US);
Jonathan Walter Stocker, Durham, NC (US);
Assignee:
Icagen, Inc., Durham, NC (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 3/1165 ; C07C / ;
U.S. Cl.
CPC ...
A61K 3/1165 ; C07C / ;
Abstract
Novel inhibitors of potassium flux are disclosed. The inhibitors show surprising resistance to degradation in biological media and enhanced in vivo half-lives relative to non-fluorine substituted homologues. Methods for the use of these compounds include treating sickle cell disease, preventing erythrocyte dehydration and inhibiting potassium flux.