The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Sep. 11, 2001
Filed:
Oct. 04, 1999
Applicant:
Inventors:
Martin Fussenegger, Zürich, CH;
Charles J. Thompson, Binningen, CH;
James E. Bailey, Zürich, CH;
Assignee:
Cistronics Cell Technology GmbH, Zurich, CH;
Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
C12N 1/509 ; C12N 1/500 ; C12N 1/579 ; C12N 5/00 ; C07H 2/104 ;
U.S. Cl.
CPC ...
C12N 1/509 ; C12N 1/500 ; C12N 1/579 ; C12N 5/00 ; C07H 2/104 ;
Abstract
The invention relates to a novel system for gene regulation in eukaryotic cells, and methods of using the same for protein production, tissue engineering and gene therapy. In particular, the invention provides a new system for antibiotic-regulated gene expression in eukaryotic cells based on sequences from Actinomycetes antibiotic resistance promoters, polypeptides that bind to the same in an antibiotic responsive manner, and nucleotides encoding such polypeptides. Further, the invention provides novel and sensitive methods of screening for candidate antibiotics.