The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Sep. 04, 2001
Filed:
Oct. 02, 1998
Applicant:
Inventor:
Lawrence J. Thomas, Easton, MA (US);
Assignee:
AVANT Immunotherapeutics, Inc., Needham, MA (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C12N 1/888 ; A61K 4/800 ;
U.S. Cl.
CPC ...
C12N 1/888 ; A61K 4/800 ;
Abstract
A plasmid-based vaccine is provided herein based on the combination of DNA segments coding for one or more B cell epitopes of cholesteryl ester transfer protein (CETP) and one or more broad range helper T cell epitopes. Administration of the plasmids as a vaccine to a vertebrate subject provides an immune response to the subject's endogenous CETP and modulation of CETP activity, leading to prevention or reversal of various manifestations of heart disease. The vaccines provide an advantageous strategy for the prevention or treatment of atherosclerosis.