The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 28, 2001
Filed:
Oct. 23, 2000
Jacobus A. J. Den Hartog, Weesp, NL;
Gerben M. Visser, Weesp, NL;
Bartholomeus J. Van Steen, Weesp, NL;
Martinus T. M. Tulp, Weesp, NL;
Eric Ronken, Weesp, NL;
Cornelis G. Kruse, Weesp, NL;
Abstract
The present invention relates to a group of novel 2-aminoquinoline derivatives which are potent and selective agonists of the dopamine D4-receptor. The compounds have general formula (I) wherein (R,),represents 1 or 2 substituents, which can be the same or different, from the group C,-alkyl or alkoxy, halogen, trifluoromethyl, nitro, amino, and mono- or dialkyl (C,)amino, or two groups R,at adjacent carbon atoms together with the benzene ring may form the benzdioxane group or benzofuran group, X represents nitrogen or carbon, and the dotted line may represent a double bond, (R,),represents 0, 1 or 2 substituents, which can be the same or different, from the group methyl and ethyl, or (R,),is a methylene bridge or ethylene bridge, R,is hydrogen or methyl, and (R),represents 0, 1, or 2 substituents, which can be the same or different and can be located at all available positions of the quinolyl group, from the group C,-alkyl or alkoxy, halogen, trifluoromethyl, nitro, amino, and mono- or dialkyl (C,)amino, on the understanding that R,cannot represent o-OCH,when X is nitrogen, (R,),and R,are hydrogen, m is 0 and n is 1