The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Aug. 28, 2001

Filed:

Aug. 13, 1998
Applicant:
Inventors:

Kenneth H. Fife, Zionsville, IN (US);

Michell D. Krathwohl, Indianapolis, IN (US);

Robert Hromas, Indianapolis, IN (US);

Darron R. Brown, Zionsville, IN (US);

Hal E. Broxmeyer, Indianapolis, IN (US);

Assignee:
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C12N 1/539 ;
U.S. Cl.
CPC ...
C12N 1/539 ;
Abstract

The inventors have cloned and expressed the chemokine-like genes from MCV type 1 and the closely related MCV type 2 in order to determine a potential role for these proteins in the viral life cycle. These are the first viral chemokines that have been shown to antagonize the chemotactic activity of human chemokines and the first viral chemokines that have been shown to have inhibitory activity on human hematopoietic progenitor cells. Methods and compositions for exploiting these proteins are disclosed herein.


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