The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 21, 2001
Filed:
Dec. 21, 1999
John David Harling, Sawbridgeworth, GB;
Barry Sidney Orlek, Epping, GB;
Mervyn Thompson, Harlow, GB;
SmithKline Beecham, p.l.c., Brentford, GB;
Abstract
Compounds of formula (I) and pharmaceutically acceptable salts thereof, where R,is hydrogen, C,alkyl (optionally substituted by hydroxy or C,alkoxy), C,alkenyl, C,alkynyl, C,alkylCO—, formyl, CF,CO— or C,alkylSO,—; R,is hydrogen or up to three substituents selected from halogen, NO,, CN, N,, CF,O—, CF,S—, CF,CO—, trifluoromethyldiazirinyl, C 1-6?alkyl, C,alkenyl, C,alkynyl, C,perfluoroalkyl, C,cycloalkyl, C,cycloalkyl-C,alkyl-, C,alkylO—, C,alkylCO—, C,cycloalkylO—, C,cycloalkylCO—, C,cycloalkyl-C,alkylO—, C,cycloalkyl-C,alkylCO—, phenyl, phenoxy, benzyloxy, benzoyl, phenyl-C,alkyl-, C,alkylS—, C,alkylSO,—, (C,alkyl),NSO,—, (C,alkyl)NHSO,—, (C,alkyl),NCO—, (C,alkyl)NHCO— or CONH,; or —NR,R,where R,is hydrogen or C,alkyl, and R,is hydrogen, C,alkyl, formyl, —CO,C,alkyl or —COC,alkyl; or two R,groups together form a carbocyclic ring that is saturated or unsaturated and unsubstituted or substituted by —OH or ═O; and the two R,groups and the two R,groups are each independently hydrogen or C,alkyl or the two R,groups and/or the two R,groups together form a C,spiroalkyl group provided that at least one R,and R,group is not hydrogen, are useful in the treatment and prophylaxis of epilepsy and other disorders.