The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 21, 2001
Filed:
Jan. 06, 1993
Christina K. Eddy, Loveland, CO (US);
BASF Aktiengesellschaft, Ludwigshafen, DE;
Abstract
The pesent invention is directed to biotin-producing recombinant cells transformed with an,bioE gene or a functional equivalent thereof, either alone or in combination with at least one additional nucleic acid sequence selected from,bioA, bioB, bioD, bioF, bioW, bioX, and bioY genes, or a functional equivalent of any of these genes. Preferred recombinant cells are capable of converting essentially all biotin vitamers to true biotin. The present invention also provides a method to produce biotin by culturing such recombinant cells under appropriate conditions in an effective medium, which preferably includes biotin precursor supplements. The present invention is also directed to recombinant cells transformed with an,bioH gene, or functional equivalent thereof, either alone or with at least one nucleic acid selected from the group consisting of,bioA, bioB, bioC, bioD, bioE, and bioF genes, and functional equivalents thereof, said recombinant cells being capable of producing more biotin than a cell not transformed with an,bioH gene, or functional equivalent thereof; and use of such cells to produce biotin.