The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 21, 2001
Filed:
Mar. 31, 1998
Lorne M. Golub, Smithtown, NY (US);
Hsi-Ming Lee, Setauket, NY (US);
Timo Sorsa, Helsinki, FI;
Olli Teronen, Helsinki, FI;
Tuula Salo, Oulu, FI;
The Research Foundation of State University of New York, Albany, NY (US);
Abstract
The invention is a method of inhibiting the activity of membrane-type matrix metalloproteinase (MT-MMP) in biological systems. Accordingly, the invention permits the treatment of medical conditions in mammals that are characterized by MT-MMP activity, and especially those conditions characterized by excessive MT-MMP activity. The method employs a tetracycline compound, preferably a non-antimicrobial tetracycline, and more preferably 6-demethyl-6-deoxy-4-de(dimethylamino)tetracycline (CMT-,) or 6-&agr;-deoxy-5-hydroxy-4-de(dimethylamino)tetracycline (CMT-,) to inhibit the MT-MMP activity.