The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Aug. 14, 2001

Filed:

Jun. 30, 1999
Applicant:
Inventors:

Takeshi Hom-ma, Tokyo, JP;

Nagayoshi Myo, Tokyo, JP;

Takaya Sato, Tokyo, JP;

Hironobu Nanbu, Mie, JP;

Assignee:

Other;

Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
A61K 9/26 ; A61K 9/14 ; A61K 9/16 ; A61K 9/50 ;
U.S. Cl.
CPC ...
A61K 9/26 ; A61K 9/14 ; A61K 9/16 ; A61K 9/50 ;
Abstract

The present inventors have made studies for the purpose of establishing a process for preparing controlled-release preparations which can rapidly release 99% or more of a slightly soluble medicament (which has by itself shows a slow dissolution rate) in the upper part of the small intestine. As a result, the inventors have succeeded in establishing a process comprising carrying a slightly soluble medicament which has a slow intestinal dissolution rate on aggregates of the spherical microparticles of a multivalent metal alginate, in which each of the secondary particles (i.e., the aggregates) has a specific surface area ranging from 1 to 280 m,/g. This success leads to the accomplishment of the present invention.


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