The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 14, 2001
Filed:
May. 26, 1994
Robert O. Ralston, Danville, CA (US);
Frank Marcus, Danville, CA (US);
Kent B. Thudium, Oakland, CA (US);
Barbara A. Gervase, Vallejo, CA (US);
John A. Hall, Rohnert Park, CA (US);
Kim M. Berger, Lafayette, CA (US);
Qui-Lim Choo, El Cerrito, CA (US);
Michael Houghton, Danville, CA (US);
George Kuo, San Francisco, CA (US);
Chiron Corporation, Emeryville, CA (US);
Abstract
Two Hepatitis C Virus envelope proteins (E1 and E2) are expressed without sialylation. Recombinant expression of these proteins in lower eukaryotes, or in mammalian cells in which terminal glycosylation is blocked, results in recombinant proteins which are more similar to native HCV glycoproteins. When isolated by GNA lectin affinity, the E1 and E2 proteins aggregate into virus-like particles.