The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 14, 2001
Filed:
Jun. 07, 1995
Cary A. Presant, San Marino, CA (US);
Richard T. Proffitt, Arcadia, CA (US);
Raymond L. Teplitz, Pasadena, CA (US);
Lawrence E. Williams, San Dimas, CA (US);
George W. Tin, Arcadia, CA (US);
Gilead Sciences, Inc., Foster City, CA (US);
Abstract
Micellular particles such as small unilamellar vesicles of less than 2000 A° loaded with,In are administered to BALB/c mice in which EMT,tumors had been induced. Whole body scintographs of the mice to which either neutral or positively or negatively charged vesicles had been administered show a substantial quantity of the vesicle entrapped,In localized in the tumor. Blocking of macrophages in the liver and spleen by first administering unlabeled, aminomannose substituted vesicles before administration of the labeled vesicles increases uptake of the,In labeled vesicles in the tumor.