Nestable, modular apparatus for synthesis of multiple organic compounds

Abstract

The simultaneous synthesis of diverse organic compounds is performed in stackable modules which are moveable among nesting sites located on work station platforms. The reactor module includes a heat transfer block adapted to receive an array of reactor vessels, preferrably in the form of solid phase extraction cartridges without sorbent, each with an outlet port. A plurality of valves are located below the vessels. The valves consist of rows of gang-controlled stopcocks which regulate the passage of fluids from the reactor vessel outlet ports into aligned channels, each formed by a pair of threated Leur tip adapters. The reactor module may be situated over a discharge module. The inlet openings in the discharge module accept the threaded ends of the Leur tip adapters. The discharge module may consist of a multi-well collector block or a drain block. An introduction module, which includes a pressure plate having an array of openings and a septum, may be received over the reactor module. The downwardly projecting rim defining each pressure plate opening cooperates with the septum to engage the mouth of the aligned reactor vessel to maintain a fluid tight seal.