The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 07, 2001
Filed:
Jun. 01, 2000
Christopher Bieniarz, Highland Park, IL (US);
Kornepati V. Ramakrishna, Libertyville, IL (US);
Christopher Behme, Lake Villa, IL (US);
Abbott Laboratories, Abbott Park, IL (US);
Abstract
A method for fluoromethylation of an alcohol via halogenative decarboxylation. The method includes the step of reacting an alcohol of the formula R,C(CX,),OH with an alpha-haloester of the formula X,CH,CO,R,to form an alpha-alkoxy ester, wherein R,is selected from the group consisting of hydrogen and alkyl groups, wherein R,is selected from the group consisting of hydrogen and alkyl groups, wherein X, at each occurrence, is independently selected from the group consisting of hydrogen, bromine, fluorine, and chlorine, and wherein X,is selected from the group consisting of bromine and chlorine. The resulting alpha-alkoxy ester is saponified to form an alpha-alkoxy acid which is heated at reflux with lead tetraacetate and a chlorinating agent to form a chloride compound of the formula R,C(CX,),OCH,Cl. The chloride compound is converted to a fluoride compound of the formula R,C(CX,),OCH,F with a fluorinating agent.