The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 07, 2001
Filed:
Jun. 19, 2000
Applicant:
Inventors:
Frans Van Dalen, Nuenen, NL;
Jacobus Maria Lemmens, Mook, NL;
Gertruda Antonetta Philomina Van Helvoirt, Nijmegen, NL;
Theororus Hendricus Antonius Peters, Arnhem, NL;
Frantisek Picha, Brno, CS;
Assignee:
Synthon BV, Nijmegen, NL;
Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
C07D / ; C07C 6/9013 ;
U.S. Cl.
CPC ...
C07D / ; C07C 6/9013 ;
Abstract
A process for the production of simvastatin and its analogues that is efficient, economical and convenient involves the use of hydroxyl protected intermediates of formula (III) or (VII). These intermediates allow for direct alkylation of the butyrate side chain followed by deprotection and reformation of the lactone ring.