The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 07, 2001
Filed:
Nov. 02, 2000
Applicant:
Inventors:
Ratna Shekhar, Madison, NJ (US);
Michael John Girgis, Montville, NJ (US);
Assignee:
Novartis AG, Basel, CH;
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07D / ;
U.S. Cl.
CPC ...
C07D / ;
Abstract
Disclosed are methods for the synthesis of amino acid amides which comprise providing a fixed bed of a cation exchange resin, admixing a primary alcohol and an amino acid in a reaction vessel in fluid communication with the fixed bed to form a first mixture, contacting the fixed bed of cation exchange resin with the first mixture for a period of time, thereby causing amino acid ester intermediate to be formed on the cation exchange resin, adding liquid ammonia to the reaction vessel, and contacting the fixed bed of cation exchange resin with ammonia, the fixed bed having previously been contacted with the first mixture.