The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 07, 2001
Filed:
Feb. 23, 1999
Applicant:
Inventors:
Ellen Ngoi Yin Cheung, Agoura, CA (US);
Thomas Charles Boone, Newbury Park, CA (US);
Susan Irene Hershenson, Newbury Park, CA (US);
John David Young, Thousand Oaks, CA (US);
Assignee:
Amgen Inc., Thousand Oaks, CA (US);
Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
C07H 2/104 ; C12P 2/106 ; C12N 1/00 ; C12N 5/00 ;
U.S. Cl.
CPC ...
C07H 2/104 ; C12P 2/106 ; C12N 1/00 ; C12N 5/00 ;
Abstract
The in vivo circulating life and/or absorption of cationic therapeutic proteins, including but not limited to basic proteins such as NT-3, can be increased by generating analogs that have a lower isoelectric point and, preferably, also a lower protein charge relative to the protein of native sequence.