The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 07, 2001
Filed:
Mar. 16, 2000
Applicant:
Inventors:
Claude Négrier, Irigny, FR;
Jean Luc Plantier, Grigny, FR;
Assignee:
Aventis Behring GmbH, Marburg, DE;
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
C12N 1/500 ; C12N 1/563 ; C12P 2/106 ; C07H 2/104 ;
U.S. Cl.
CPC ...
C12N 1/500 ; C12N 1/563 ; C12P 2/106 ; C07H 2/104 ;
Abstract
A modified Factor VIII cDNA is described comprising deletion of the B-domain and insertion of at least one truncated Factor IX intron 1 in the Factor VIII cDNA. The modified Factor VIII cDNA may be used for the production of a high yield of Factor VIII in vitro. The modified Factor VIII cDNA may be incorporated into a vector for gene therapy.