The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jul. 31, 2001
Filed:
May. 27, 1999
Applicant:
Inventors:
Nicholas B. La Thangue, Glasgow, GB;
Lasantha R. Bandara, Abingdon, GB;
Assignee:
Prolifix Limited, Abingdon, GB;
Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
A01N 3/718 ; A61K 3/800 ; C01K 1/400 ; C01K 1/600 ; C01K 1/700 ;
U.S. Cl.
CPC ...
A01N 3/718 ; A61K 3/800 ; C01K 1/400 ; C01K 1/600 ; C01K 1/700 ;
Abstract
The invention provides a polypeptide consisting essentially of a sequence corresponding to residues 163 to 199 of DP-1 as shown in the Figure, and fragments and variants thereof capable of antagonising the heterodimerization of a DP protein with an E2F protein. Such peptides may be used to induce apoptosis in a cell by introducing into the cell an effective amount of said peptide. Such cells include cardiovascular cells, and the peptide may be delivered in a stent to treat or prevent restinosis.