The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jul. 31, 2001
Filed:
Jun. 12, 1998
Applicant:
Inventors:
Claudio Bordignon, Milan, IT;
Fulvio Mavilio, Milan, IT;
Assignee:
Roche Diagnostics GmbH, Mannheim, DE;
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
C12N 1/563 ; C12N 1/585 ; A61K 3/500 ;
U.S. Cl.
CPC ...
C12N 1/563 ; C12N 1/585 ; A61K 3/500 ;
Abstract
In the course of therapy following an allogeneic bone marrow transplant (allo-BMT) in which lymphocytes were removed from the transplant, donor lymphocytes are introduced after a delay to reconstitute immunity in the patient. According to the invention, these donor lymphocytes are transduced with a detectable cell surface marker and a suicide gene prior to introducing them into the patient. Introduction of these transduced lymphocytes after allo-BMT, serves to treat or prevent complications from the BMT, including disease relapse, reactivation of viral infection and Graft versus Host disease.