The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Jul. 17, 2001

Filed:

Feb. 13, 1997
Applicant:
Inventors:

Britton Chance, Marathon, FL (US);

Vasilis Ntziachristos, Philadelphia, PA (US);

Assignee:

Non-Invasive Technology, Philadelphia, PA (US);

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61B 5/00 ;
U.S. Cl.
CPC ...
A61B 5/00 ;
Abstract

A spectroscopic system for quantifying in vivo concentration of an absorptive pigment in biological tissue includes an oscillator for generating a first carrier waveform of a first frequency on the order of 10,Hz, a light source for generating light of a selected wavelengths modulated by the carrier waveform, and a detector for detecting radiation that has migrated over photon migration paths in the tissue from an input port to a detection port spaced several centimeters apart. The wavelength is sensitive to concentration of an absorptive pigment present in the tissue. A phase detector compares the detected radiation with the introduced radiation and determines therefrom the phase shift of the detected radiation. A processor quantifies the concentration of the absorptive pigment by calculating a value of the absorption coefficient.


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