The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Jul. 17, 2001

Filed:

May. 04, 2000
Applicant:
Inventors:

Douglas J. M. Allen, New London, CT (US);

Troy Anthony Appleton, East Lyme, CT (US);

Michael Jon Gumkowski, Old Lyme, CT (US);

David Joseph Muehlbauer, North Stonington, CT (US);

Timothy Norris, Gales Ferry, CT (US);

Assignee:

Pfizer Inc., New York, NY (US);

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 3/1435 ; A61K 3/1445 ; C07D / ; A61P 1/08 ;
U.S. Cl.
CPC ...
A61K 3/1435 ; A61K 3/1445 ; C07D / ; A61P 1/08 ;
Abstract

Two crystalline polymorphic forms of (2-Benzhydryl-1-azo-bicyclo(2.2.2]Octyl-3-yl)-(5-iso-propyl-2-methoxybenzyl)amine dihydrochloride dihydrate are Form I and Form II. The pharmaceutical composition containing at least are of these polymorphs has advantageous stability for formulation to treat emesis in patients receiving chemotherapy. The administration of this pharmaceutical composition is conventional oral by preferably tablet or capsule or intravenous. A method of making Forms I and II is also disclosed.


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