The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jul. 17, 2001
Filed:
Mar. 11, 1999
Niels Peter Hundahl Møller, Copenhagen Ø, DK;
Henrik Sune Andersen, Lyngby, DK;
Lars Fogh Iversen, Holte, DK;
Ole Hvilsted Olsen, Brønshøj, DK;
Sven Branner, Lyngby, DK;
Daniel Dale Holsworth, San Diego, CA (US);
Farid Bakir, San Diego, CA (US);
Luke Milburn Judge, La Jolla, CA (US);
Frank Urban Axe, Escondido, CA (US);
Todd Kevin Jones, Solana Beach, CA (US);
William Charles Ripka, San Diego, CA (US);
Yu Ge, San Diego, CA (US);
Roy Teruyuki Uyeda, San Diego, CA (US);
Other;
Abstract
The present invention provides novel compounds, novel compositions, methods of their use, and methods of their manufacture, where such compounds are pharmacologically useful inhibitors of Protein Tyrosine Phosphatases (PTPase's) such as PTP1B, CD45, SHP-1, SHP-2, PTP&agr;, LAR and HePTP or the like. The compounds are useful in the treatment of type I diabetes, type II diabetes, impaired glucose tolerance, insulin resistance, obesity, immune dysfunctions including autoimmunity diseases with dysfunctions of the coagulation system, allergic diseases including asthma, osteoporosis, proliferative disorders including cancer and psoriasis, diseases with decreased or increased synthesis or effects of growth hormone, diseases with decreased or increased synthesis of hormones or cytokines that regulate the release of/or response to growth hormone, diseases of the brain including Alzheimer's disease and schizophrenia, and infectious diseases.