The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Jul. 03, 2001

Filed:

Jan. 20, 1999
Applicant:
Inventors:

Jung Ho Kim, Daejeon, KR;

Tae Neung Jhong, Kyonggi-do, KR;

Young Ki Paik, Seoul, KR;

Joon Seo Park, Daejeon, KR;

Eui Deok Kim, Daejeon, KR;

You Suk Lee, Seoul, KR;

Seung Un Kim, Daejeon, KR;

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07D / ; C07D / ; A61K 3/14375 ; A61K 3/14355 ;
U.S. Cl.
CPC ...
C07D / ; C07D / ; A61K 3/14375 ; A61K 3/14355 ;
Abstract

The present invention provides a cholesterol biosynthesis inhibitor which specifically inhibits the sterol 14-reductase which is involved in the distal pathway of cholesterol biosynthesis, a compound of formula (1) below and the use of an extract or the compound of formula (1) for treating hypercholesterolaemia or hyperlipidaemia. The inhibitor comprises an extract obtained by extracting,with a solvent, or an organic layers obtained by partitioning an extract from,with an organic solvent. The extract contains 7,8,13,13&agr;-tetrahydrocoridaline or its derivative, as the active ingredients, which specifically inhibits the enzyme which is involved in the distal pathway of the cholesterol biosynthesis.


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