The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 19, 2001
Filed:
Jun. 27, 2000
Masahumi Kitano, Takatsuki, JP;
Kazuhiro Nakano, Osaka, JP;
Hideki Yagi, Osaka, JP;
Naohito Ohashi, Takatsuki, JP;
Atsuyuki Kojima, Takarazuka, JP;
Tsuyoshi Noguchi, Toyonaka, JP;
Akira Miyagishi, Takatsuki, JP;
Sumitomo Pharmaceuticals Co., Ltd., Osaka, JP;
Abstract
Novel indoloylguanidine derivatives shown by formula (1), wherein R,represents one or more, the same or different substituent(s) which is selected from the group consisting of a hydrogen atom, an alkyl group, a substituted alkyl group, an alkenyl group, an alkynyl group, a cycloalkyl group, a halogen atom, nitro group, an acyl group, carboxyl group, an alkoxycarbonyl group, an aromatic group, and a group shown by formula: —OR,, —NR,R,, —SO,NR,R,or —S(O),R,; and R,represents a hydrogen atom, an alkyl group, a substituted alkyl group, a cycloalkyl group, hydroxy group, an alkoxy group or a group shown by formula: —CH,R,; and which inhibit the Na,/H,exchanger activity and are useful for the treatment and prevention of a disease caused by increased Na,/H,exchanger activity, such as hypertension, arrhythmia, angina pectoris, cardiac hypertrophy, diabetes, disorders associated with ischemia or ischemic reperfusion, cerebro-ischemic disorders; or diseases caused by excessive cell proliferation.