The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 19, 2001
Filed:
Mar. 10, 1994
Manfred Motz, München, DE;
Erwin Soutscheck, München, DE;
Renate Fuchs, Deisenhofen, DE;
Bettina Wilske, München, DE;
Vera Preac-Mursic, München, DE;
Mikrogen Molekularbiogische Entwicklungs - GmbH, Munich, DE;
Abstract
Various immunologically active proteins from,have been prepared by genetic manipulation in microorganisms. To do this, the specific DNA sequences were selected from a,gene bank using suitable screening methods, or were prepared directly by DNA amplification using selected hybridization probes, and were placed under the control of inducible promoters such as, for example, the lac promoter. It has been possible, owing to description of efficient purification methods for the expressed antigens, to provide the proteins in a suitable way. These proteins can be used to produce specific and sensitive diagnostic assay kits. The specific combination of the immunologically active proteins makes precise diagnosis possible. Furthermore, monoclonal antibodies have been generated and are used as reagents for detecting pathogens directly in test samples or after cultivation. The,-specific DNA sequences can be employed for direct detection of the pathogen in patients' samples (for example by means of the PCR reaction).