The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 12, 2001
Filed:
Sep. 21, 1999
Applicant:
Inventors:
Bert Vogelstein, Baltimore, MD (US);
Kenneth W. Kinzler, BelAir, MD (US);
Michael I. Sherman, Allendale, NJ (US);
Assignee:
Other;
Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
C12Q 1/68 ; C07H 2/100 ; C07H 2/102 ; C07H 2/104 ; C07H 1/900 ;
U.S. Cl.
CPC ...
C12Q 1/68 ; C07H 2/100 ; C07H 2/102 ; C07H 2/104 ; C07H 1/900 ;
Abstract
Specific sequences in the human genome are the sites of strong binding of wild-type p53 protein, but not mutant forms of the protein. These sequences are used diagnostically to detect cells in which the amount of wild-type p53 is diminished. The sequences can also be used to screen for agents which correct for loss of wild-type p53 to DNA in cancer cells.