The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 05, 2001
Filed:
Sep. 28, 1999
Applicant:
Inventors:
Jacques Pelleter, Reims, FR;
Marie-Jeanne Pasquet, Reims, FR;
Thomas Geoffrey Colerick Bird, Reims, FR;
Assignee:
Other;
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07F 9/06 ; C07F 9/02 ;
U.S. Cl.
CPC ...
C07F 9/06 ; C07F 9/02 ;
Abstract
Processes for preparing compounds of the formula (I) are described: P,OOC—CH(OH)—CHR,—CONH—Z wherein P,is hydrogen or a protecting group, Z is a group —CHR,COOP,or —CHR,CONR,R,wherein P,is hydrogen or a protecting group and R,-R,are values known in the TNF-inhibitor art. The compounds of the formula (I) are useful in inhibiting TNF and one or more matrix metalloproteinase enzymes. One intermediate in a process of the invention is formula (II).